Fight Candida, Thrush, and Other Yeast Overgrowths

Last Updated: May 15, 2019 | First Published: June 25, 2018
Reviewed by: Dr. Ahmed Zayed, M.D.

Monolaurin and Yeast Infections Biofilm Disruptor

Monolaurin & Yeast Infections

Introduction

Yeast infections, or candida overgrowth, are becoming increasingly common in women, affecting up to 75% (Ref #1) of women at some point in their lifetime. A yeast infection, also known as candidiasis, is an opportunistic human fungal infection that occurs either in the mouth and throat as thrush, the genitourinary tract as vaginal candidiasis, and the skin as cutaneous candidiasis. The fungal infection produces its symptoms by the formation of biofilms and the attacking of the immune system.

Current treatment for yeast infections include antifungal agents; however, there is a rise in antifungal resistance because of its widespread use. Furthermore, an infection is increasingly difficult to treat without the risk of chronic reinfection. Since fungal infections are becoming even more common, and there is a growing antifungal resistance, there is a need for a search in new and effective treatments (Ref #2). There is an excellent interest in the investigation of natural compounds as antifungal medications because they can be found easily in food and plant sources (Ref #3). Monolaurin is a natural compound that has been found to have antifungal activity against candida, including candida albicans.

Fighting Candidiasis with Natural Alternatives

Candida Albicans, the fungus causing thrush and yeast infections, is opportunistic and its targets are those who have weak immune systems. In these immunocompromised individuals, the fungus creates biofilms, a closely packed community of cells that when mature, are characterized by dense communities of yeasts.

Monolaurin, the biologically active form of lauric acid, is a medium-chain fatty acid found in coconut oil that may help regulate immune function. One study demonstrated the use of lauric acid to be highly effective in the treatment of candida albicans (Ref #4). To help promote immune response and digestive health, monolaurin has been shown in studies to disrupt the protective fat coating (Ref #5) of organisms so that they cannot attach and enter a host cell.

A number of studies have delved into the role of monolaurin as an alternative natural compound to boost immune response and combat antifungal resistance. The studies have found that monolaurin can support in the following:

Monolaurin might halt biofilms and reduce inflamation

  • A study (Ref #6) found that treatment of candida biofilms with monolaurin significantly reduced yeast concentration. In addition to this, monolaurin was able to cause anti-inflammatory responses which indicate that the infection was stopped dead in its track towards

Monolaurin may be effective at killing candida at even small doses

  • Another study (Ref #7) found that small doses of monolaurin were already effective in the killing of candida versus the use of capric acid which required a higher dose to kill candida.

Monolaurin may kill Candida albicans

  • Yet another study (Ref #5) found that monolaurin was most effective against Candida albicans, a species of candida, followed by Staphylococcus.

From these examples, we can can observe that monolaurin when used in laboratory settings expresses antifungal behaviors that are capable of stopping the production of symptoms of candidiasis.

Conclusion

As antifungal resistance becomes increasingly widespread, and the growing difficulty of effectively treating fungal infections, monolaurin, a natural compound, is a welcome addition to the arsenal of antifungal treatments. It has been shown to be effective in the killing of candida in these lab studies and avoiding symptoms from appearing with the use of minimal doses.

 

References

  1. M. C. Stoppler. Yeast Infection (in Women and Men). MedicineNet. https://www.medicinenet.com/yeast_infection_in_women_and_men/article.htm

  2. P. Vandeputte, S. Ferrari, & A. T. Coste. Antifungal Resistance and New Strategies to Control Fungal Infections. International Journal of Microbiology. December 2011. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236459/

  3. C. V. Martins, D. L. Silva, A. T. Neres, T. F. Magalhaes, G. A. Watanabe, L. V. Modolo, M. A. Resende. Curcumin as a promising antifungal of clinical interest. Journal of Antimicrobial Chemotherapy. 26 November 2008. https://pdfs.semanticscholar.org/562e/46ba09678fdc5103b9c163d6f5386f501651.pdf

  4. G. Bergsson, J. Arnfinsson, O. Steingrimsson, & H. Thormar. In vitro killing of Candida albicans by fatty acids and monoglycerides. Journal of Antimicrobial agents and chemotherapy. November 2001. http://www.ncbi.nlm.nih.gov/pubmed/11600381

  5. V. O. Ezigbo, E. A. Mbaegbu. Extraction of Lauric Acid from Coconut Oil, Its Applications and Health Implications On Some Microorganisms. African Journal of Education, Science and Technology. April 2016. http://www.coou.edu.ng/journals/ajest/vol_3_iss_2/extraction_of_lauric_acis_from_coconut_oil.pdf

  6. D. Saleem, E. Chen, B. Benso, V. Pardi, & R. M. Murata. In vitro evaluation of antifungal activity of monolaurin against Candida albicans biofilms. PeerJ. 2016. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924139/pdf/peerj-04-2148.pdf

  7. G. Bergsson, J. Arnfinnsson, O. Steingrimsson, & H. Thormar. In Vitro Killing of Candida albicans by Fatty Acids and Monoglycerides. Antimicrobial Agents and Chemotherapy. 2001. http://aac.asm.org/content/45/11/3209.full