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Monolaurin and L-Lysine – Better Together

Last Updated: January 8, 2019 | First Published: August 13, 2018
Reviewed by: Dr. Razak Nohri, Pharm.D, M.Phil, MBA

Working together, L-lysine may reduce the symptoms and duration of an HSV outbreak while Monolaurin may work to destroy the virus reducing recurrence.

Working together, L-lysine may reduce the symptoms and duration of an HSV outbreak while Monolaurin may work to destroy the virus reducing recurrence.

Lysine and Monolaurin may play a role in clearing, containing, or preventing viral infections such as Herpes Simplex Virus (HSV). Lysine is a natural amino acid, which the body cannot produce on its own. L-lysine must be obtained from food sources or through medically approved supplements containing the amino acid.

Monolaurin is formed in the body when food containing glycerine and lauric acid is consumed. It is unknown exactly how much the body converts, making supplementation necessary for therapeutic quantities. 

L-Lysine: Promising Research in the treatment of HSV

In one study (Ref #1, 2), control groups were given L-lysine monohydrochloride daily to study the effects of lysine on the rate of recurrence on Herpes Simplex Virus (HSV). The study reported that L-lysine is extremely effective in slowing down the occurrence of HSV infections, reducing symptoms, and healing time was significantly reduced.

In another study (Ref # 3), a randomized, double-blind, placebo-controlled, cross-over study of forty-one patients it was found that oral ingestion of L-Lysine monohydrochloride shows evidence of decreasing the recurrence rate of herpes simplex attacks in nonimmunocompromised hosts. L-Lysine may be capable of decreasing the severity of symptoms associated with HSV recurrences.

A third study (Ref #4) showed L-lysine has an inhibitory effect on the multiplication of herpes simplex virus in cell cultures. The study included 65 patients in a double-blind, placebo-controlled, crossover study. In the study, significantly more patients were recurrence-free during lysine than during placebo treatment, suggesting that certain patients may benefit from prophylactic lysine administration.

Effects Of L-Lysine and Monolaurin on HSV

L-lysine and Monolaurin have shown the ability to slow the occurrences of the Herpes Simplex Virus (Type 1 and Type 2) in laboratory studies, and may produce positive results when combined.

L-lysine for reducing symptoms and duration of an HSV Infection 

L-lysine may help to reduce the occurrence of HSV breakouts. As noted in the research above, l-lysine has been shown in some laboratory studies to help reduce the severity and duration of HSV breakouts.

Monolaurin for disabling the HSV virus

Monolaurin has been shown to assist with disabling the HSV virus, as detailed in previous Insights articles. This can help prevent the virus from reproducing, and may decrease the risk of transmission. Additionally, monolaurin has also been shown to dissolve the HSV virus in some laboratory studies suggesting Monolaurin may be able to kill HSV. 

When combining L-lysine and Monolaurin, the results can be advantageous. While L-lysine may slow the occurrence of HSV symptoms and duration of breakouts, Monolaurin may dissolve the virus and eventually kill the virus over time.


  1. Griffith R.S.,Norins A.L., Kagan C. A Multicentered Study of Lysine Therapy in Herpes simplex Infection. Dermatologica 1978;156:257–267

  2. Griffith R.S., Walsh D.E., Myrmel K.H., Thompson R.W., Behforooz A. Success of L-Lysine Therapy in Frequently Recurrent Herpes simplex Infection. Dermatologica 1987;175:183–190

  3. McCune MA , Perry HO , Muller SA , O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis. 1984 Oct;34(4):366-73. \

  4. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol. 1980;60(1):85-7.


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