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Monolaurin and Digestion – What animal studies may suggest about monolaurin’s effect on digestive bacteria (archaea).

Last Updated: February 22, 2019 | First Published: February 18, 2019
Reviewed by: Dr. Jennifer Meza, M.D.

Could animal studies demonstrate the potential for Monolaurin to help regulate gut bacteria?

Could animal studies demonstrate the potential for Monolaurin to help regulate gut bacteria?

Introduction:

Farm animals may have digestive complications not unlike some people. Veterinarians, doctors, and pharmacists alike are continuously looking for remedies which don’t cause unwanted side effects like antibiotic resistance, destroying of “good” gut bacteria, etc.

In this article, we explore two types of bacteria which effect farm animals and monolaurin’s potential part to play in supporting a healthier life of these animals.

Archaebacteria specifically, ruminal methanogens (bacteria in farm animals which cause greenhouse gas methane)

Archaebacteria (sometimes referred to as archaea) are a diverse group of bacteria which are separated into three major groups: methanogens, halophiles, and thermophiles. The methanogens are anaerobic bacteria that produce methane and are found in sewage treatment plants, bogs, and the intestinal tracts of ruminants. [1] In farm animals, these bacteria case the bi-product of methane which is a problem for two reasons: methane is a greenhouse gas which contributes to climate change, and methane produced in the rumen (a special area of the digestive system which breaks down animal feed and plant matter) causes a loss of up to 12% of the animal’s energy derived from its food [2]. Methane produced from livestock accounts for 50% of all the greenhouse gas methane produced from human activity. [3]

Farmers and scientists searching for a way to lower the methane produced by farm animals have looked to reduce and eliminate this bacterium from the digestive tract of farm animals.

In one study, Monolaurin was able to eliminate Fibrobacter succinogenes and Methanomicrobiales below detectable limits. Total Archaea were decreased by up to over 90% [4]

“Monolaurin completely inhibited Fibrobacter succinogenes in all diets while the response of the other cellulolytic bacteria varied in dependence of the diet… total Archaea were decreased by up to over 90% … monolaurin exerted variable effects mediated by unknown mechanisms on important ruminal microbes involved in carbohydrate degradation, along with its suppression of methane formation.” [4]

In another study, monolaurin was shown to inhibit methanogenesis, increase cell membrane permeability, and decrease survival of M. ruminantium.[3]

“C12 (Lauric Acid) and C14 (myristic acid) had the strongest effect on cell viability, as 57% and 64% of the cells were categorized as dead after 3 h, while in the C16 (palmitic acid) group only 32% of cells were dead or, as part of the cells were not red but yellow, damaged. At 24 h, nearly all cells treated with C12 and C14 were dead, compared to 60% of dead cells found in the control. “ [3]

Archaea may potentially be pathogenic in humans [10], and these results show that monolaurin may be an effective option for eliminating harmful and unwanted gut bacteria including Archaebacteria without adverse side effects.

Enterococcus faecalis (a type of bacteria typically present in the digestive tract, but can spread and cause disease in other parts of the body)

Enterococcus faecalis is a Gram-positive, commensal bacterium which is found in the gastrointestinal tracts of humans and other mammals. Enterococci of animal origin can cause infections in humans and be quite dangerous for those with bloodstream infections and in hospital environments. [5]

Infections commonly caused by enterococci include urinary tract infection (UTIs), endocarditis, bacteremia, catheter-related infections, wound infections, and intra-abdominal and pelvic infections. Many infecting strains originate from the patient's intestinal flora. From here, they can spread and cause UTI, intra-abdominal infection, and surgical wound infection. Enterococci are surprisingly resistant to many pharmaceuticals including penicillin, making them increasingly difficult to treat. [7]

One study showed that Monolaurin and Lauric Acid were effective in disrupting Enterococcus faecalis and associated biofilms:

“Both Glycerol Monolaurate (monolaurin) and lauric acid were effective in inhibiting biofilm development as measured by decreased numbers of viable biofilm-associated bacteria as well as decreased biofilm biomass. Compared with lauric acid on a molar basis, GML represented a more effective inhibitor of biofilms formed by either S. aureus or E. faecalis.” [8]

Another study goes on to demonstrate that monolaurin may be able to suppress the growth of antibiotic-resistant E. faecalis in the lab:

"We found that Glycerol Monolaurate (GML) suppresses growth of vancomycin-resistant Enterococcus faecalis on plates with vancomycin and blocks the induction of vancomycin resistance, which involves a membrane-associated signal transduction mechanism, either at or before initiation of transcription. Given the surfactant nature of GML and the results of previous experiments, we suggest that GML blocks signal transduction." [11]

The ability of monolaurin to stop the growth of Enterococcus faecalis, even strains which are resistant to antibiotics, is promising for those who may suffer from an infection from this bacteria.

Other studies on ruminal methanogenesis

A study in the UK used monolaurin to suppress methanogenesis in cows using a mixture of lauric (C12) and myristic acids (C14). [6] The study indicates that monolaurin might help curb the production of methane, a greenhouse gas, in farm animals by destroying the source bacteria in their gut.

“The present study demonstrated a clear synergistic effect of mixtures of C12 and C14 in suppressing methanogenesis, mediated probably by direct inhibitory effects of the fatty acids on the methanogens.” [6]

A study in Belgium showed that the use of coconut oil, when added to animal feed, can help reduce dietary methane production:

“Both krabok oil and coconut oil increased the rumen volatile fatty acids, in particular propionate and decreased acetate proportions. Protozoal numbers were reduced through the supplementation of a medium chain fatty acid source (coconut oil, krabok oil), with the strongest reduction by krabok oil.” [10]

Potential application for human digestion

These studies demonstrated how monolaurin may be applied to supplement animal feed to reduce targeted bacterial colonies and biofilms without negatively impacting “good” gut bacteria or contributing to antibiotic resistance.

While the studies are focused on the commercial application for farm animals, there may be potential to apply some of the lessons to humans. As stated before, same or similar bacteria can cause pathogenic infections in people. If monolaurin can effectively treat these bacterium in animal studies, there may be potential to apply to humans, but further research is needed.

With all supplements, it is important that you consult a medical professional before beginning a supplement regimen.

References:

  1. The Columbia Electronic Encyclopedia, 6th ed. 2012, Columbia University Press.

  2. Hook SE, Wright AG, McBride 1. “Methanogens: Methane Producers of the Rumen and Mitigation Strategies” Archaea, Volume 2010, Article ID 945785, 11 pages, http://dx.doi.org/10.1155/2010/945785

  3. Xuan Zhou, Leo Meile, Michael Kreuzer, and Johanna O. Zeitz, “The Effect of Saturated Fatty Acids on Methanogenesis and Cell Viability of Methanobrevibacter ruminantium,” Archaea, vol. 2013, Article ID 106916, 9 pages, 2013. https://doi.org/10.1155/2013/106916.

  4. Klevenhusen F, Meile L, Kreuzer M, Soliva CR. Effects of monolaurin on ruminal methanogens and selected bacterial species from cattle, as determined with the rumen simulation technique. Anaerobe. 2011 Oct; 17(5):232-8. doi: 10.1016/j.anaerobe.2011.07.003.

  5. Hammerum AM. “Enterococci of animal origin and their significance for public health.” Clin Microbiol Infect. 2012 Jul;18(7):619-25. doi: 10.1111/j.1469-0691.2012.03829.x

  6. C. R. Soliva, L. Meile, A. Cieślak, M. Kreuzer, and A. Machmüller, “Rumen simulation technique study on the interactions of dietary lauric and myristic acid supplementation in suppressing ruminal methanogenesis,” British Journal of Nutrition, vol. 92, no. 4, pp. 689–700, 2004.

  7. Fraser, S.L. “Enterococcal Infections” Medscape. Updated 30 July 2018. Last accessed 19 February 2019.

  8. Donavon J. Hess, Michelle J. Henry-Stanley, and Carol L. Wells. Surgical Infections. Volume: 16 Issue 5: October 5, 2015.

  9. Holly E. Saito, John R. Harp, Elizabeth M. Fozo. Enterococcus faecalis Responds to Individual Exogenous Fatty Acids Independently of Their Degree of Saturation or Chain Length. Appl. Environ. Microbiol. Dec 2017, 84 (1) e01633-17; DOI: 10.1128/AEM.01633-17

  10. Paul B. Eckburg, Paul W. Lepp, David A. Relman. Archaea and Their Potential Role in Human Disease. Infection and Immunity Feb 2003, 71 (2) 591-596; DOI: 10.1128/IAI.71.2.591-596.2003

  11. Ruzin A, Novick RP. Glycerol monolaurate inhibits induction of vancomycin resistance in Enterococcus faecalis. J Bacteriol. 1998 Jan;180(1):182-5.

Monolaurin and Gastritis

Last Updated: January 8, 2019 | First Published: August 20, 2018
Reviewed by: Dr. Jennifer Meza, M.D.

Treating Stomach Ulcers (caused by H. Pylori) with Monolaurin

The number of ulcer-related cases presented in hospitals is between 500k and 900k per year.

The number of ulcer-related cases presented in hospitals is between 500k and 900k per year.

An ulcer is a sore area or a hole in the lining of the stomach. Ulcers of the stomach and the small intestine are mostly caused by a spiral-shaped bacteria called Helicobacter pylori (H. Pylori), and they can affect people from any age group (Ref #1). Gastritis is a disease that causes ulcers in the stomach through inflammation in the inner lining of the stomach. It can be caused by various factors including excessive consumption of alcohol or a normal dose of some medications like anti-inflammatory drugs.

Symptoms of Gastritis

The most common symptom is the pain in the upper abdomen area. When the lining of the stomach becomes inflamed, a burning sensation can be felt in this area of the body as it is in direct contact with the stomach. Patients may experience this pain in the early hours of the morning, on an empty stomach, and between meals. This pain may be relieved by using antacids, but not always. Accompanying symptoms can include hiccups, upset stomach, indigestion, vomiting and no appetite for days (Ref #2).

A diagnosis of an H. Pylori infection may take a long time, as doctors tend to omit these specific tests or assume that an ulcer is responsible for the overgrowth of the bacteria.                       

Monolaurin and H. Pylori Bacteria

Monolaurin is a medium chain fatty acid that can be extracted from coconut oil and has been shown to possess antibacterial properties (Ref #3). According to some laboratory studies, Monolaurin may kill H. Pylori bacteria, and in turn may be an effective treatment for gastritis.

Monolaurin displays a strong anti-bacterial behavior against H. pylori as compared to other chemicals. One study (Ref #4) showed that Monolaurin was the most effective of the fatty acids and monoglycerides tested in the killing of H. Pylori. Furthermore, the results were not impacted by pH, suggesting that Monolaurin might work in the hard acidity of the stomach.

A further study (Ref #5) shows that H. pylori is rapidly inactivated by medium-chain monoglycerides and lauric acid (Monolaurin) and exhibits a relatively low frequency of spontaneous development of resistance to the bactericidal activity of Monlaurin. Monolaurin was shown to be bactericidal agsint H. Pylori bacteria in as little as 15 minutes at neutral or acidic pHs.

Monolaurin does not appear to harm any useful gut bacteria. A research study of 2004 conducted in the Georgetown University Medical Centre of Washington DC revealed that Monolaurin could be very useful in treating infections as it is a safe compound that can be combined with other antibiotics as well (Ref #6). Since then, it has been used as an active ingredient in some anti-bacterial medicines. It is used to treat some common diseases like cold and swine flu.

Conclusion

In recent years, monolaurin has been studied for treating microorganisms, fungi, and bacteria that pose a threat to health. Research has indicated the potential of Monolaurin as an antibacterial agent as it has the power to inactivate bacteria in the laboratory. Like all dietary supplements, Monolaurin should be considered and administered under the supervision of a healthcare professional.  

 

References

  1. Kusters JG, van Vliet AHM, Kuipers EJ. Pathogenesis of Helicobacter pylori Infection. Clinical Microbiology Reviews. 2006;19(3):449-490. doi:10.1128/CMR.00054-05. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1539101/

  2. IQWiG (Institute for Quality and Efficiency in Health Care) June 28, 2018 Accessed athttps://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0078820/

  3. Bergsson G, Steingrímsson O, Thormar H. Bactericidal effects of fatty acids and monoglycerides on Helicobacter pylori. Int J Antimicrob Agents. 2002 Oct;20(4):258-62. https://www.ncbi.nlm.nih.gov/pubmed/12385681

  4. Sun CQ, O'Connor CJ, Roberton AM. Antibacterial actions of fatty acids and monoglycerides against Helicobacter pylori. FEMS Immunol Med Microbiol. 2003 May 15;36(1-2):9-17. https://www.ncbi.nlm.nih.gov/pubmed/12727360

  5. Petschow BW, Batema RP, Ford LL. Susceptibility of Helicobacter pylori to bactericidal properties of medium-chain monoglycerides and free fatty acids. Antimicrob Agents Chemother. 1996 Feb;40(2):302-6. https://www.ncbi.nlm.nih.gov/pubmed/8834870

  6. Preuss HG, Echard B. Enig M. Brook I, Elliott TB. Minimum inhibitory concentrations of herbal essential oils and monolaurin for gram-positive and gram-negative bacteria. Molecular and Cellular Biochemistry April 2005, Volume 272, Issue 1–2, pp 29–34 https://doi.org/10.1007/s11010-005-6604-1

Monolaurin and Food-Borne Bacterial Pathogens

Last Updated: January 7, 2019 | First Published: July 27, 2018
Reviewed by: Dr. Ahmed Zayed, M.D.

The Potential Effectiveness Of Monolaurin In The Elimination Of Foodborne Bacterium Species

Can Monolaurin help combat foodborne illness caused by mishandling of meat or exposure during international travel?

Can Monolaurin help combat foodborne illness caused by mishandling of meat or exposure during international travel?

Monolaurin, a compound found in coconut oil and considered a healthy by-product of the fats found in coconut, is gaining momentum in scientific studies and healthcare systems recently. The compound has now been associated with a number of potential health benefits, including improvements in immune system function and to assist in the treatment of certain skin-related conditions.

Studies are now turning their focus to the antimicrobial properties of monolaurin – not only to assist in treating bacterial and viral infections among patients but also as a solution to inhibit the growth and eliminate the presence of live pathogenic microorganisms in contaminated food products.

Foodborne Infections – A Global Concern

Foodborne diseases are becoming a threat in several countries. Several bacterial species have been identified to contaminate food and, when ingested, cause infection in the human body. Pathogenic microorganisms (Ref #1) like Clostridium botulinum, Y. Pseudotuberculosis, Escherichia coli, Vibrio spp, Enterococcus spp, and Listeria monocytogenes, are all of concern. These bacterium species can cause deadly bacterial infections, including urinary tract infections, endocarditis, the E. coli infection, and even meningitis.

These microorganisms can contaminate food without a person knowing it. When proper hygiene practices are not implemented at home or at a butchery, for example, bacteria may find their way into food.

When traveling to a new destination, food can also be contaminated with new species that are not commonly found in the traveler’s country. Outdoor activities like camping, picnicking, visiting street markets, etc. may also increase the risk of food being contaminated with pathogenic microorganisms.

Monolaurin In The Elimination Of Pathogenic Microorganisms

Monolaurin has been shown to be an effective compound used in the fight against both bacterial and viral infections. The compound may also help to reduce the risk of antibiotic resistance in patients being treated with pharmaceutical antimicrobial agents, and may also be a useful option for treating antibiotic resistance in patients who do not seem to respond well to such pharmaceutical drugs.

A paper by the Institute of Food Technologies (Ref #2) has  provided evidence that the use of Monolaurin as a coconut oil extraction may be a good option for fighting against the global concerns surrounding bacterial contamination in food products.

The study explains that monolaurin holds powerful antimicrobial actions that can help to eliminate the presence of certain bacterium strains in food that may be contaminated. Monolaurin seems to be effective against the bacterium species Bacillus subtilis and Escherichia coli (E. coli) when the compound is combined with another substance known as EDTA, or ethylenediaminetetraacetic acid.

E. Coli is a gram-negative bacteria commonly associated with foodborne illness and food poisoning. Research suggests that monolaurin is effective in killing gram-negative bacteria and E. Coli (Ref #3). Monlolauin may enter the cell membrane of E. Coli, thus disintegrating and killing the bacteria (Ref # 4). Monolaurin my help with digestive problems caused by E. Coli, as well as urinary tract infections.

Additional studies revealed that a mixture of Monolaurin and antimicrobial nisin might be an appropriate option for the treatment of food products contaminated with Staphylococcus aureus bacteria, another bacteria which can be spread with the mishandling of food. (Ref #5)

A further study looked at the antimicrobial effects of Monolaurin against Entamoeba histolytica (E. histolytica) and Giardia lamblia (G. lamblia), which are common causes of diarrhea and malabsorption in humans. You can get Giardia lamblia from eating contmainted food or drinking contaminated water. The research suggests that monolaurin was effective in eliminating Giardia after infection, but even more interestingly helped prevent infection in the first place (Ref #6). 

References

  1. Ortega, Y. R. (2008). Foodborne Diseases. Emerging Infectious Diseases, 14(7), 1181. http://doi.org/10.3201/eid1407.080346

  2. http://apps.who.int/iris/bitstream/handle/10665/199350/9789241565165_eng.pdf?sequence=1

  3. Beuchat LA. Comparison of antiviral activities of potassium sorbate, sodium benzoate and glycerol and sucrose esters of fatty acids. Appi. Environ. Microbiol. 39:1178, 1980http://pubmedcentralcanada.ca/pmcc/articles/PMC291503/

  4. Kabara JJ. The Pharmacological Effect of Lipids. Champaign, Ill, USA: American Oil Chemist’s Society; 1978. Page 92 https://goo.gl/1CcpaV

  5. Zhang H, Wei H, Cui Y, Zhao G, Feng F. Antibacterial interactions of monolaurin with commonly used antimicrobials and food components. J Food Sci. 2009 Sep;74(7):M418-21. doi: 10.1111/j.1750-3841.2009.01300.x.

  6. Fahmy ZH, Aly E, Shalsh I, Mohamed AH. The effect of medium chain saturated fatty acid (monolaurin) on levels of the cytokines on experimental animal in Entamoeba histolytica and Giardia lamblia infection. African Journal of Pharmacy and Pharmacology. January 2014.

Monolaurin and Digestive Health - How to Help and Repair a Leaky Gut

Last Updated: January 4, 2019 | First Published: July 6, 2018
Reviewed by: Dr. Ahmed Zayed, M.D.

Leaky gut can lead to other health problems - can Monolaurin help repair a leaky gut?

Leaky gut can lead to other health problems - can Monolaurin help repair a leaky gut?

Digestive health is central to overall health because the digestive system is where nutrients from food are absorbed and then transported throughout the body for use in various processes. The digestive system is also on the frontlines of fighting disease by being home to a gut microbiome, a community of disease-fighting and health-maintaining microorganisms like bacteria. So, a healthy gut is a healthier you; however, as digestive health is compromised, so is your body.

Leaky gut contributes to this compromised health state, as it takes in toxic waste products and unabsorbed food particles along with desired nutrition. In turn, these waste products are transported throughout the body thus reducing overall health. This is where monolaurin comes into play: Monolaurin may help improve our intestinal ecosystem, our gut microbiome, and in turn our overall health.

Repairing a Leaky Gut with Monolaurin

In a leaky gut, the barrier inside the bowel that was once effective in the absorption of nutrients malfunctions and allows the entry of large molecules and germs producing a wide spectrum of symptoms. Leaky gut is associated with chronic fatigue syndrome, asthma, autism, lupus, multiple sclerosis, scleroderma, migraines and even food allergies (Ref #1). In this situation, the gut microbiome is compromised. Monolaurin then becomes a key player in this sense.

Monolaurin, the biologically active form of lauric acid, is a medium-chain fatty acid found in coconut oil that is capable of destroying fungi, bacteria, and viruses. The bacteria that pass through the intestinal barrier also can be destroyed by monolaurin.  By virtue of being a medium-chain fatty acid, monolaurin has antimicrobial effects as well as a positive effect on the immune system. Studies have investigated the effect of medium-chain fatty acids on the gut microbiome and found that these kinds of fatty acids had a protective effect on intestinal structure (Ref #2).

To discuss further, monolaurin as a medium-chain fatty acid has been found to have roles in the gut and metabolic health in the following ways:

1. Supporting gut microbiome and fighting obesity: 

A study (Ref #3) has found that consumption of medium-chain fatty acids such as monolaurin from coconut oil helped in remodeling the gut microbiome by altering the distribution of good bacteria where they were needed the most. In addition to this, taking monolaurin was also shown to have anti-obesity properties.

2. Aiding nutrition absorption:

Since medium-chain fatty acids are more likely to be absorbed by the gut compared to long-chain fatty acids, a study (Ref #4) found that taking medium-chain fatty acids lead to an improvement in fat malabsorption in patients diagnosed with HIV, indicating an increase in their nutrition states.

3. Help fight malnutrition:

Another study (Ref #5) found that in patients with short bowel syndrome, medium-chain fatty acids provided calories even with minimal prior digestion.

Conclusion

Digestive and gut health is essential to holistic health, and monolaurin can aid in restoring digestive health by promoting a healthy intestinal flora, increasing the ability to absorb fat, and providing calories. Monolaurin can help you get more positive results from food as well as kill the harmful bacteria that get into the system because of a leaky bowel.

 

References

  1. “Leaky gut syndrome”. NHS Choices. https://www.nhs.uk/conditions/leaky-gut-syndrome/

  2. N. Dierick, J. Decuypere, & I. Degeyter. The Combined Use Of Wholecupheaseeds Containing Medium Chain Fatty Acids And An Exogenous Lipase In Piglet Nutrition. Archives of Animal Nutrition. February 2003.https://www.ncbi.nlm.nih.gov/pubmed/12801079

  3. S. Rial, A. Karelis, K. Bergeron, & C. Mounier. Gut Microbiota and Metabolic Health: The Potential Beneficial Effects of a Medium Chain Triglyceride Diet in Obese Individuals. Nutrients. 2016. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882694/

  4. C. A. Wanke, D. Pleskow, P. C. Degirolami, B. B. Lambl, K. Merkel, & S. Akrabawi. A medium chain triglyceride-based diet in patients with HIV and chronic diarrhea reduces diarrhea and malabsorption: A prospective, controlled trial. Nutrition. 1996.https://www.sciencedirect.com/science/article/pii/S0899900796002213

  5. N. Shah, & B. Limketkai. The Use of Medium-Chain Triglycerides in Gastrointestinal Disorders. Nutrition Issues in Gastroenterology. February 2017.http://mctlift.com.br/site/artigos/1.pdf

Support your Digestive System and Promote a Healthy Gut with Monolaurin

Last Updated: December 3, 2018 | First Published: November 6, 2015
Reviewed by: Dr. Felix Boakye-Agyeman, M.D., Ph.D

Could Monolaurin help relieve gastric issued causes by H. Pylori?

Could Monolaurin help relieve gastric issued causes by H. Pylori?

Suffering from indigestion? Heart burn? Diarrhea?  Dull pains in the abdomen? Loss of appetite or lethargy? These symptoms can be the result from a number of ailments, but one which often goes undiagnosed is H. Pylori.

H. Pylori (Helicobacter Pylori) is bacteria which infects the stomach and gut and can cause complications like Gastritis or even Gastro-Esophageal Reflux Disease (GERD).

Diagnosing H. Pylori may take time - they are usually misdiagnosed, and treatment can include expensive and harsh drugs which include proton pump inhibitors (eg. Protonics, Prevacid and Nexium), histamine (H-2) blockers (eg. Zantac) and Pepto-Bismol.

A natural and healthy alternative for treating H. Pylori may include a daily therapy of Monolaurin. Monolaurin, derived from coconut, is a natural antimicrobial supplement and is shown to kill bacteria including H. Pylori without harming desirable gut bacteria or causing bacteria drug resistance.

Benefits of Monolaurin for treating H. Pylori:

Monolaurin is a natural and superior treatment for H. Pylori overgrowth for three main reasons:

  1. Monolaurin is highly effective in killing H. Pylori with minimal side effects

    • Research may demonstrate that monolaurin is highly effective in quickly killing and eliminating H. Pylori regardless of stomach pH [1]. Some studies show that monolaurin kills over 99.99% of gram negative bacteria including H. Pylori, and is accomplished safely with minimal side effects [2].

  2. Monolaurin does not harm desirable gut bacteria

    • A healthy gut contains a significant amount of beneficial bacteria which aid in digestion and absorption of nutrients. Many people take probiotics to help restore healthy levels of gut flora after damaging effects of antibiotics, laxatives, or poor diet. Monolaurin does not appear to have an adverse effect on this desirable gut bacteria and targets only potentially harmful microorganisms. One study reported no inactivation of the common (healthy) Escherichia coli (E. coli) or Salmonella enteritidis by monolaurin, but major inactivation of Hemophilus influenza, Staphylococcus epidermis, and Group B gram positive streptococcus. [3]

  3. Monolaurin does not cause bacterial resistance

    • Unlike pharmaceuticals / antibiotics, Monolaurin is natural and does not cause bacteria such as H. Pylori to become resistant to treatment. This is extremely important if you suffer from chronic infections or require long term treatment. Monolaurin is shown to be highly effective even against resistant or difficult to treat bacterial infections of H. Pylori [4, 5].

Natural Cure Labs Monolaurin treatment

If you are looking to treat H. Pylori without harsh or expensive drugs, monolaurin may be a great natural alternative.

A recommended Monolaurin dosage for treating existing or new infections is 1-2 capsules 2-3 times daily.  For those who have recently overcome an infection and want to maintain good digestive health, 1-2 capsules 1-2 times daily can be effective. 

# Caps* x Per Day Duration
New or Existing H. Pylori infection 2-3 capsules 2-3 times per day 6 weeks or until gone
Maintain a Healthy Gut 1-2 capsules 1-3 times per day Ongoing
*Capsules based on 600mg / capsule

For more detailed guidance on dosage, please see the Monolaurin Dosing Guide. 

As any natural treatment, it is safest and most effective when done under the supervision of a health care professional .

References:

  1. Bergsson G, Steingrı́msson O, Thormar H. Bactericidal effects of fatty acids and monoglycerides on Helicobacter pylori. International Journal of Antimicrobial Agents. Volume 20, Issue 4, October 2002, Pages 258–262

  2. Sun CQ, O’Connor CJ, Roberton AM. Antibacterial actions of fatty acids and monoglycerides against Helicobacter pylori. FEMS Immunology and Medical Microbiology 36 (2003) p 9-17

  3. Isaacs CE, Thormar H. The role of milk-derived antimicrobial lipids as antiviral and antibacterial agents. Advances in Experimental Medicine and Biology. 1991; 310:159-65

  4. Preuss HG, Echard B, Enig M, Brook I, Elliott TB. Minimum inhibitory concentrations of herbal essential oils and monolaurin for gram-positive and gram-negative bacteria. Molecular and Cellular Biochemistry. 2005 Apr;272(1-2):29-34.

  5. Petschow BW, Batema RP, Ford LL. Susceptibility of Helicobacter pylori to bactericidal properties of medium-chain monoglycerides and free fatty acids. Antimicrobial Agents and Chemotherapy. February 1996 vol. 40 no. 2 302-306

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