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Filtering by Tag: Straphylococcus Aureus

Monolaurin and Staph / MRSA

Last Updated: January 7, 2019 | First Published: July 30, 2018
Reviewed by: Dr. Ahmed Zayed, M.D.

Is Monolaurin Effective In The Treatment Of Staph And MRSA?

Staph infections which can become MRSA are a growing problem. Could Monolaurin overcome antibiotic resistance plaguing hospitals and patients alike?

Staph infections which can become MRSA are a growing problem. Could Monolaurin overcome antibiotic resistance plaguing hospitals and patients alike?

Healthcare systems are challenged by the widespread prevalence of Staphylococcus Aureus related infections. This bacterium is considered pathogenic and causes different types of bacterial infections (Ref #1) in patients. Infections from this bacterium can be obtained in general community settings, as well as in hospitals.

Treatment remains a challenge due to the increased number of Methicillin-Resistant Staphylococcus aureus (MRSA) infections being reported, a strain of the bacteria that quickly becomes resistant to standard pharmaceutical protocols used to treat such infections.

The Impact Of Staphylococcus Aureus Infections

A paper (Ref #2) published in the Journal of Clinical Microbiology Reviews estimates that up to 30% of the global human population may be colonized with the Staphylococcus Aureus bacterium which can cause MRSA. Upon a weakening of the immune system, the bacterium can multiply and cause infection. The population is exposed to these pathogenic bacterial microorganisms through different means. One study (Ref #3) in the Journal of Infection and Public Health found that up this bacterium may be present in up to 16.4% of meat products found in local stores, and the Methicillin-Resistant (MRSA) strains in up to 1.2% of these meat products.

Staphylococcus aureus bacteria can cause (Ref #4) skin infections and pneumonia and contributes to infections related to food poisoning. The bacterium has also been linked to bacteremia, as well as toxic shock syndrome.

Monolaurin: A Potential Antimicrobial Agent Against Staph and MRSA Infections

Monolaurin has presented the potential to be used as an antimicrobial agent in patients with infections related to the Staphylococcus aureus bacterium. One study (Ref #5) explains that glycerol monolaurate, another name for monolaurin, contains an active compound known as lauric acid. Even though the bacteria cause glycerol monolaurate to be hydrolyzed, the lauric acid content seems to inhibit the activity of the Staphylococcus aureus bacteria. Additionally, it has also been noted that monolaurin may be effective in preventing the bacteria from becoming resistant to a common drug used to treat such bacterial infections, known as Vancomycin.

A study (Ref #6) conducted on mice also found that monolaurin is an effective antimicrobial agent. The study compared the effects of this substance to the use of Origanum oil. The bacteria killed all untreated mice in seven days. More than 60% of the mice that were treated with a combination of origanum oil and monolaurin survived the bacterial infection. The combination of monolaurin and Vancomycin also proved as an effective approach to the treatment of the infection.

References

  1. Taylor TA, Unakal CG. Staphylococcus Aureus. [Updated 2017 Oct 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK441868/

  2. Tong, S. Y. C., Davis, J. S., Eichenberger, E., Holland, T. L., & Fowler, V. G. (2015). Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management. Clinical Microbiology Reviews, 28(3), 603–661. http://doi.org/10.1128/CMR.00134-14

  3. Hanson BM, Dressler AE, Harper AL, Scheibel RP, Wardyn SE, Roberts LK, Kroeger JS, Smith TC. “Prevalence of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) on retail meat in Iowa.” J Infect Public Health. 2011 Sep;4(4):169-74. doi: 10.1016/j.jiph.2011.06.001. Epub 2011 Jul 19.

  4. https://medlineplus.gov/staphylococcalinfections.html

  5. Ruzin A, Novick RP. “Equivalence of lauric acid and glycerol monolaurate as inhibitors of signal transduction in Staphylococcus aureus.” J Bacteriol. 2000 May;182(9):2668-71.https://www.ncbi.nlm.nih.gov/pubmed/10762277

  6. Preuss HG, Echard B, Dadgar A, Talpur N, Manohar V, Enig M, Bagchi D, Ingram C. “Effects of Essential Oils and Monolaurin on Staphylococcus aureus: In Vitro and In Vivo Studies.” Toxicol Mech Methods. 2005;15(4):279-85. doi: 10.1080/15376520590968833.https://www.ncbi.nlm.nih.gov/pubmed/20021093

The Role of Monolaurin in the Treatment of Bacterial Infections

Last Updated: December 14, 2018 | First Published: June 11, 2018
Reviewed by: Dr. Ahmed Zayed, M.D.

There have been many laboratory studies on the Monolaurin and bacteria

There have been many laboratory studies on the Monolaurin and bacteria

Bacterial infections are relatively common today. While the use of antibiotics has been an effective approach to the treatment of these infections for many years, modern-day healthcare systems are recognizing the increased prevalence of antibiotic resistance. One study [Ref #1] explains that the widespread resistance against antibiotic drugs is caused by the misuse and the overuse of antibiotics. Untreated bacterial infections, even in the case of antibiotic resistance, can lead to fatal complications.

Different types of bacterial infections have been identified in human patients [Ref #2]. These infections can often be classified as primary or secondary, as well as either acute or chronic. A bacterial infection can also be localized, pyogenic or generalized. Infections can affect different parts of the body, including the lungs, the throat, the gums, stomach, and other areas.

Monolaurin In The Treatment Of Infection

The human body is a host to billions of microorganisms, including bacteria. While many of these organisms are beneficial for the human body, some of them can be pathogenic, which means they cause harm. The infestation of pathogenic bacteria species in the human body can lead to the development of an infection.
This calls for the scientists to start looking at alternative options for the treatment of bacterial infections. Many natural treatments have been suggested for the use against the presence of an infection caused by bacterium species in the human body, but only a few of these substances hold clinically significant data behind their effectiveness. Monolaurin is one particular substance that has been proven effective.

Monolaurin is a naturally-derived medium chain fatty acid that can be extracted from glycerin and lauric acid [Red#3]. The substance is also a coconut fat byproduct. While this substance has become quite popular in the preservation of food, recent studies have started to take a look at the use of Monolaurin in bacterial infections.

Numerous scientific studies have been conducted and proven the effectiveness of Monolaurin in the treatment of infections caused by specific types of bacterium species.

  • Straphylococcus Aureus – This bacteria can cause skin infections, pneumonia, endocarditis, sepsis, meningitis, osteomyelitis, and more. The species have also been associated with toxic shock syndrome. One study [Ref #4] found the extracts of Monolaurin from coconut oil, combined with an agent known as lactic acid, very effective in the treatment of bacterial infections caused by the Staphylococcus aureus species. The study explains that Monolaurin resulted in a loss of membranes and cytoplasm in Staphylococcus aureus bacteria cells.

  • Enteroccocus – A group of bacterium species that often causes wound infections, as well as infections in soft tissue within the human body. One study [Ref #5] found the use of Monolaurin extracts to be statistically significant when the effects of this extract were tested on Staphylococcus aureus, Enterobacter spp, Enterococcus spp, E. vulneris, and Streptococcus spp. All of the tests performed in these studies were performed on samples obtained from skin infections.

  • Escherichia Coli – Often referred to as E. coli, when pathogenic, these bacteria can cause infections to develop in the intestines, leading to gastrointestinal discomfort, pain and other accompanying symptoms. Studies have proven Monolaurin concentrations of 20mg/ml to be effective in reducing colony growth density in human subjects.

Conclusion

Infections caused by bacteria can cause life-threatening complications. Antibiotics are the conventional treatment option used to eliminate the presence of a bacterial infection, but with an increased prevalence of antibiotic resistance, the world is looking for alternative methods to help treat these infections. Monolaurin has the potential to assist with the elimination of infections caused by particular types of bacterium species.

Lean more about the bacterium Monolaurin has been researched to treat on the Research page

References

  1. C. L. Ventola. The Antibiotic Resistance Crisis. Journal of Pharmacy and Therapeutics. April 2015. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378521/

  2. J.W. Peterson. Bacterial Pathogenesis. Medical Microbiology. 4th edition. https://www.ncbi.nlm.nih.gov/books/NBK8526/

  3. J. Seladi-Schulman. What Is Monolaurin? Healthline. 22 August 2017. https://www.healthline.com/health/monolaurin

  4. P. Tangwatcharin, P. Khopaibool. Activity of virgin coconut oil, lauric acid or monolaurin in combination with lactic acid against Staphylococcus aureus. U.S. National Library of Medicine. July 2012. https://www.ncbi.nlm.nih.gov/pubmed/23077821

  5. B.G. Carpo, V.M. Verallo-Rowell, J. Kabara. Novel antibacterial activity of monolaurin compared with conventional antibiotics against organisms from sin infections: an in vitro study. U.S. National Library of Medicine. October 2007. https://www.ncbi.nlm.nih.gov/pubmed/17966176

Doctor, author and fitness enthusiast, Ahmed Zayed, MD, is a surgery resident with a passion for helping people live a happy healthy life. Dr. Zayed is a contributing author for Natural Cure Labs.

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